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Motawi TK, Sadik NAH, Hamed MA et al (2020) Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinsons disease mice model

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The core chelation site relies on the imidazole ring of histidine and the side chain amino group of lysine to ensure the controlled release of copper ions

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Additionally, Glutathione S-transferase zeta 1 (GSTZ1) [93] and Sigma-1 receptor (SIR) [94] improved the sensitivity of HCC cells to sorafenib-induced ferroptosis by down-regulating NRF2

The lipid hydroperoxide (ROOH) is unstable in the presence of iron or other metal catalysts because ROOH will participate in a Fenton reaction leading to the formation of reactive alkoxy radicals