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Studies have shown that caffeic acid can inhibit the expression of Keap1, reduce the stabilization of the Keap1 and Nrf2 complex, thereby activate Nrf2 and upregulate the expression of downstream antioxidant enzymes NQO1 and HO-1 ( Morin, a type of flavonol, is obtained from the wood of the Morus alba plant and has a variety of biological activities, including antioxidant, hypoglycemic, and liver protection

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Table 1 Antidiabetic effects of peptides and protein hydrolysates identified from plants and their cognitive dysfunction

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Pieces of the Puzzle The general features of hyperglycemia-induced tissue damage are shown schematically in Fig