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When CDs are dispersed in high-concentration solvents, the distance between CD particles is extremely short and with high surface energy

That said, careless stacking can backfire, leading to hormone suppression, insulin sensitivity issues, or overuse side effects

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10.1016/S0092-8674(04)00130-8 65 ChiuC

That said, the clinical evidence for routine 5-MTHF in over-35s without an MTHFR polymorphism remains limited, and folic acid at the 400 g dose remains the guideline-backed default