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The resulting supernatants were diluted 20-fold with PBS buffer before analysis using the established ratio fluorescence immunoassay method

Mutations in the SNCA gene promote -syn aggregation into oligomers or fibrils, which disrupt the ubiquitin-proteasome system and impair membrane binding by reducing its N-terminal -helical structure, leading to compromised membrane integrity and increased permeability (141, 142)

Understanding these targets, the mechanisms of apoptotic signaling pathways, and identifying additional factors that trigger or inhibit the apoptotic process could represent potential therapeutic strategies to enhance erythrocyte health and overall human well-being

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& Mori-Yoshimura, M.), 119 (Springer, 2015)