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138 short sleep and insomnia as independent predictors of obesity, hypertension, and diabetes

attract immune and endothelial cells to injury sites

The analysis was done after the fact rather than as a primary endpoint, and the clocks were measured in blood, so they track systemic aging rather than the brain in particular

Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]