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Toxicol Sci 112:521531 Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

PMID: 27663781, PMCID: PMC5896554, DOI: 10.1093/ntr/ntw248

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Selenium is a vital cofactor for glutathione peroxidase (GSH-Px), which catalyzes the reduction of HO to HO using reduced GSH, thereby mitigating oxidative damage at the cellular level