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M., Hsu J., Ferguson M., et al., A Brain Network for Deep Brain Stimulation Induced Cognitive Decline in Parkinson's Disease, Brain 145, no

Together, these findings indicate that while strong oxidants, such as H 2 O 2 , favor irreversible thiol overoxidation and suppress disulfide chemistry, reactive nitrogen species provide a physiologically relevant pathway for disulphide cross-linking of TTR

Proposed mechanisms for the role of iron in neurodegeneration include increased oxidative stress, possibly due to enhanced generation of reactive oxygen species (ROS) associated with increased protein aggregation [26, 117]

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Chiu ST, Hsieh FJ, Chen SW, Chen CL, Shu HF, Li H