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10.1371/journal.pone.0126313

(2003) showed that, in a large number of Japanese patients, the presence of neither an enzyme activity-reducing mutation ( CYP2D6 10A ) nor activity-increasing mutations (duplications) in CYP2D6 alone could appreciably predict HAL concentrations

Etiology TED is most frequently associated with hyperthyroidism, constituting of approximately 90% of the cases

Circulation 143 , 935948 (2021)

doi: 10.1186/1472-6890-7-6 74 AgarwalASharmaRNallellaKThomasAAlvarezJSikkaS

The potential energy inherent in the electron gradient is used to drive the synthesis of ATP when protons flow back across the membrane through another enzyme complex, ATP synthase