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GSH is synthesized in a two-step reaction catalyzed by -glutamylcysteine synthetase and GSS in the -glutamyl cycle, which includes an additional four enzymes (Figure 1)

Six patients suffered from thalassemia major (TM), four from sickle cell disease (SCD) and two of them from severe congenital neutropenia (SCN)

Z-CZ: Resources, Software, Writing original draft, Data curation

Anticalin Technology developed by Pieris Pharmaceuticals that modifies lipocalins, which are natural extracellular proteins that bind to and transport a variety of ligands, to make therapeutics that target a specific molecule

Alliance 2 (5), e201900563

Abstract Maintaining the balance of a cells redox function is key to determining cell fate