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The genes activated by the Nrf2/ARE pathway are responsible for producing Phase II liver detoxification enzymes and powerful endogenous antioxidants

del Cura-Gonzalez I Article: CARDIOVASCULAR DRUGS AND THERAPY

Approximately 90 to 95% of circulating cortisol in plasma is found bound to proteins that make it unavailable for biological activity (Hellhammer et al., 2009)

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While complete cartilage regeneration remains beyond current capabilities, peptide support may slow degradation and promote whatever repair potential exists