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Haematopoietic stem cells (HSCs) are a group of pluripotent stem cells found in haematopoietic tissues that can differentiate and produce a variety of mature blood cells (red blood cells, macrophages, platelets, lymphocytes, etc.) to maintain the normal physiological functions of living organisms [118]

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Nat Immunol 18:374384 [DOI] [PMC free article] [PubMed] [Google Scholar] Visser K, van der Heijde D (2009) Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature