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The reactivity of Cys with oxidants is known to be pH and environment sensitive, with this arising partly from the increased reactivity of the thiolate (RS ) over the neutral form 33 , but also from electronic and structural factors [cf

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As apparent from the discussion above, there are a wide variety of pathologic and degenerative disorders which are impacted by either the level of GSH and/or ratio of oxidized to reduce species, or secondary influences based on said level or ratio

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BajicVPVan NesteCObradovicMZafirovicSRadakDBajicVBet alGlutathione redox homeostasis and its relation to cardiovascular disease