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Results: ACNs exert protective effects on MSDs by targeting multiple key signaling pathways, including mitogen-activated protein kinase (MAPK), nuclear factor-kappaB (NF-B), Wingless-related integration site (Wnt)/-catenin, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), adenosyl monophosphate-dependent protein kinase (AMPK), receptor activator of nuclear factor-kappa/receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANK/RANKL/OPG) and oxidative stress signaling

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GA acquired the funding

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As expected, serum ALT, AST, IL-1 and IL-1 concentrations were strongly reduced in GSDME WT mice by MeCbl, while GSDME C180A or GSDME D270A mice were resistant to liver injury and inflammatory response from BDL model (Fig

Subjects were instructed to maintain their routine food intake and physical activity throughout the course of the study