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GM-CSF granulocytemacrophage colony-stimulating factor, RhBMP recombinant human bone morphometric proteins, PTH 134 parathyroid hormone 134, IGFBP-3 recombinant human IGF binding protein-3, IGF-1 insulin-like growth factor-1, HGF hepatocyte growth factor, RhPDGF-BB recombinant human platelet-derived growth factor-BB, FGF-1 fibroblast growth factor-1, NGF nerve growth Factor, RhEGF recombinant human epidermal growth factor, RhGDF-5 recombinant human growth differentiation factor-5 Bone tissue repair While bone tissue possesses a self-healing capacity, critical defects or fractures resulting from trauma or surgical resection are difficult to repair autonomously, particularly in patients with metabolic diseases such as osteoporosis and diabetes

in vivo microenvironment characteristics