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While severe inborn errors of folate metabolismsuch as those causing homocystinuriaare rare and typically result from deletions or deleterious mutations that abolish enzyme function, their dramatic clinical consequences have underscored the critical importance of this metabolic pathway [1-3]

[177] She received six nominations at the 2021 MTV Video Music Awards, including her second nomination for Video of the Year

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doi: 10.1128/aac.02689-18 287 Nalley LT

Hrycay EG, Bandiera SM

By July 2025, she maintained HbA1c 5.3% and stable weight, showing sustained improvement