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Thus, the brain is more susceptible to diseases like Alzheimers disease (AD), which is closely associated with oxidative damage

These findings underscore the therapeutic potential of paraxanthine for improving cognitive function, especially in younger individuals

10.1016/j.immuni.2024.04.025 78 MaoL.LuJ.WenX.SongZ.SunC.ZhaoY.et al (2025)

Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1

Furthermore, a deficiency in Zip7 shifts macrophage activation towards an M2 phenotype, as evidenced by increased expression of the M2 marker CD206 and reduced levels of the M1 marker NOS2, along with lower production of proinflammatory cytokines such as TNF- and IL-6