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1986), and in the case of antiandrogen drugs, the flutamide nitro group is reduced to the nitroso group (in the presence of cyclodextrins) or substituted with the phenol group (in water) (Sortino et al

UW228 shows partial sensitivity to SMO inhibitors and transient suppression of GLI1, with resistance mechanisms involving SUFU downregulation or GLI2 amplification

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Similar to other cancers, dysregulation of cell cycle proteins is common in MM, resulting in aberrant cycles of cell division that contribute to pathogenesis

Small GTPases