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Topical applications of TGF-1 have also been shown to speed up wound closure, angiogenesis, inflammation, and ECM deposition in aged rats [83], and similar results were exhibited in human venous ulcer wounds using TGF-2 [84]

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The explicit goal is to achieve therapeutic efficacy by triggering a specific molecular signaling cascade rather than relying on high-concentration tissue saturation [1, 4]

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