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Conclusion TBI drives changes to cerebral and systemic metabolism that reduce aerobic metabolism of glucose in the brain and compensate by upregulating alternative pathways such as anaerobic glycolysis, lactate fermentation, gluco/ketogenic amino acid metabolism, and lipid metabolism

457 Iron, an important modulator of oxidative stress, also contributes to the dystrophic pathology

Appl Microbiol Biotechnol 93:21352145