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Instead, as proteins are a major target of HOCl-mediated damage, we will briefly describe the general bacterial strategies to maintain a healthy proteome during redox imbalance and then highlight the role of redox-regulated chaperones which have been the subject of intensive research during the past years

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doi: 10.1136/gutjnl-2020-323426 256 TakadaKShimokawaMTakamoriSShimamatsuSHiraiFTagawaTet al

Adult-onset ornithine transcarbamylase (OTC) deficiency unmasked by the Atkins diet

Metformin inhibits the production of reactive oxygen species from NADH:ubiquinone oxidoreductase to limit induction of interleukin-1 (IL-1) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages

In light of these findings, we postulated that long-term fluctuating glycemia, especially after extra carbohydrate intake, continuously and waveringly generates extra ROS, which in turn damages the pancreatic -cells