chac1 glutathione Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Glutathione (GSH) depletion by ChaC1
Glutathione (GSH) depletion by ChaC1 results in a more oxidizing Download Scientific Diagram Calcium channel mutants rescue the effect of glutathione depletion. (A) Download Scientific Diagram CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget The CHAC1 inhibited Notch3 pathway is involved in temozolomide induced glioma cytotoxicity ScienceDirect journal club Kidney International Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv
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