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[25], with hypertrophy defined as above 115 g/m 2 for men and 95 g/m 2 [24] and an enlarged left atrium defined as above 34 mL/m 2

Its clinical program in the late 2000s was built around large, rigorously controlled trials with a hard imaging endpoint (visceral adipose tissue measured by CT), and it culminated in FDA approval in 2010

Most cases result from tumors within the sella turcica or their treatment, such as surgery and radiation, though other causes exist

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"But IgG antibodies never cross the cell layers and they can never make it inside the cysts." This limitation is crucial, he added, because the interior of each cyst -- essentially a sealed chamber lined with epithelial cells -- is the location where disease-driving activity occurs