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James McKoy, MD Rheumatologist (former) Kaiser Permanente Moanalua Medical Center Moanalua, Hawaii OnabotulinumtoxinA (Botox, Botox Cosmetic) Botox - Cervical dystonia, severe primary axillary hyperhidrosis, strabismus, blepharospasm, neurogenic detrusor overactivity, chronic migraine, upper limb spasticity Botox Cosmetic - Moderate to severe glabellar lines, moderate to severe lateral canthal lines, known as crows feet AbobotulinumtoxinA (Dysport) - Upper and lower limb spasticity, cervical dystonia, and moderate-to-severe glabellar lines in adults

CNFs, Cellulose nanofibers

Aggregated proteins can trigger immune responses that intact proteins do not

Not FDA-approved as an injectable drug

Interestingly, the expression of PNPLA2 and PNPLA3 oppose one another, with expression of PNPLA2 highest during conditions that promote TAG hydrolysis such as fasting, while the expression of PNPLA3 is highest during conditions that promote TAG synthesis such as feeding (62, 63)

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