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We demonstrate that high levels of mut-p53, through binding to NRF2 and impairing its canonical antioxidant activities, directly promote ROS accumulation in cancer cells

If your brain glucose level is now elevated, you are going to produce within the brain higher levels of fructose and produce within the brain uric acid

Can Res 68:13691377 Liu E, Wu J, Cao W, Zhang J, Liu W, Jiang X, Zhang X (2007) Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma

F., Guo, Y

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels