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Furthermore, the identification of additional metabolic regulators and signaling pathways that regulate glutamine metabolism in cancer and immune cells presents a feasible solution

Estrogen upregulates the expression of Nrf2 via estrogen receptor (ER), which may explain the observation that premenopausal women exhibit different patterns of exercise-induced antioxidant upregulation compared to men [189, 190]

doi: 10.1016/j.apsb.2025.12.006 50 MohamedN.HendawyA

Equally important, the biomarker may be causal to NASH and reveal new pathways that drive the development of liver disease that may represent new biological targets for NASH therapeutics