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Although LB density seemed normal in KP with and without FLG mutations, all KP patients displayed aberrant LB internal structures, suggesting defective loading of lipid contents into the organelles of the keratinocytes

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Eight (32%) cases emerged between 12 - 18 months, 3 (12%) patients developed epilepsy between 18 - 24 months, and 2 (8%) patients had their first seizures more than 24 months later

Biotin (B7) is essential for converting food into energy, with a special focus on promoting healthy skin, hair, nails, and eyes

The detection results were calculated and recorded in strict accordance with the manufacturer instructions, as previously described [22, 23]

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