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Cancer Cell 41 , 12421260.e1246 (2023)

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium

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Importantly, while the up-regulation of ribosomal and functional genes tightly correlates with stress mitigation, the current correlative evidence cannot definitively distinguish whether this transcriptomic shift acts as the primary driver of functional repair or emerges as a secondary consequence of the plants overall improved physiological health