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36,37 Zonula occludens (ZO), including ZO-1 and its homologs ZO-2 and ZO-3, is a group of PDZ-related scaffolding proteins that belong to the superfamily of membrane-associated guanylate kinase-like proteins, possessing sites of three tandem PDZ domains at the N-terminus 38,39 (Figure 1)

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M1 macrophages exhibit bactericidal, pro-inflammatory, and anti-tumor functions, whereas M2 macrophages are primarily involved in tissue repair and anti-inflammatory processes and pro-tumor activities 88

C7018-16G, 17119818, 17151716), the Health and Medical Research Fund (HMRF, grant no

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