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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Historically, most studies in the field of reactive species and nonenzymatic processes in living organisms were focused on free radical oxidation and glycation, related to reactive oxygen species (ROS) and reactive carbonyl species (RCS) in particular

While research has identified associations between PSD and specific symptoms, the intricate interrelationships within these clusters remain largely unexplored

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[50], who demonstrated that A 2A Rs activation in endothelial cells disrupts tight and adherens junctional molecules, increases BBB permeability, and facilitates the penetration of circulating toxic molecules, such as proinflammatory cytokines, which might contribute to AD pathology

These findings persisted across the bipolar mood states and even in euthymic bipolar patients, relative to the control group (265)