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Future efforts should focus on improving sensitivity, standardization, and accessibility, while leveraging single-cell and spatial omics to capture intratumoral heterogeneity and accelerating the translation of these methodologies into clinical practice

Notably, while excess iodine is well known to trigger thyroid autoimmunity in susceptible individuals, evidence from the literature is reassuring that an adequate iodine status (defined as a UIC between 100 g/L and 299 g/L) is safe in this regard [25, 26]

Ca 2+ acts as a pivotal regulator in the excitation-contraction coupling of cardiomyocytes and serves as an essential second messenger in the control of metabolic activities, apoptotic pathways, and transcriptional regulation[125]

In addition, the GPx1 regulation of local H 2 O 2 level realized by binding TRAF2 is distinct from the regulatory action of Prx1, which forms a mixed disulfide with ASK1 to relay the oxidation signal 47

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