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Apoptosis and necrosis: different execution of the same death

40 Nifant'EvI

PMID: 37680473 iScienceTOPK mediates immune evasion of renal cell carcinoma via upregulating the expression of PD-L1

We detected higher oxidized states of Cys 170 of phosphofructokinase (PFK), Cys 247 of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Cys 379/80 of phosphoglycerate kinase (PGK) and Cys 49 and Cys 326 of pyruvate kinase M (PKM), which were all reported to interfere with either the primary or secondary function of these enzymes 32,33,34,35

doi: 10.1016/j.mcpro.2024.100881 63 GluthA.XuZ.FifieldL

"22.7% is not 25%, so some people were disappointed about that," he said, however adding that the firm believes there is "continued potential for developing CagriSema further," including by extending the trial period and overall dosage