chac1 er stress glutathione degradation Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells CHAC1 degradation of glutathione enhances

CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Cell Death & Disease Regulation of ChaC1. Oxidative and ER stress, and viral infection Download Scientific Diagram Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect ChaC1 based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells Cell Death Discovery The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2: Cell Reports

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