glutathione increases in cancer cells is critical for NK cell-mediated immunity Tumor-targeted glutathione oxidation catalysis with

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Glutathione reductase requires FAD to regenerate two molecules of reduced glutathione from oxidized glutathione

Similarly, in T cell-driven graft-versus-host disease (GVHD), FXR agonism exacerbated mortality, while T cell-specific FXR deletion or UDCA administration (again exhibiting FXR antagonistic properties) improved outcomes ( 3.1.2 Takeda G protein-coupled receptor 5 modulators: harnessing biased agonism TGR5, predominantly activated by secondary BAs like lithocholic acid (LCA) and DCA, exerts immunomodulatory effects ( 3.1.3 Therapeutic utility of specific bile acids: UDCA/TUDCA and emerging candidates Beyond their roles as ligands for specific BARRs, certain BAs themselves are used or being investigated as therapeutic agents due to their pleiotropic effects

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5.3 Chemical structure modification Chemical structure modification, including synthesizing analogs and designing prodrugs, is another effective approach