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Cheng C-F, Ku H-C, Lin H (2018) PGC-1 as a Pivotal Factor in Lipid and Metabolic Regulation

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2008 Sep;52(3):519-30

Tumor necrosis factor (TNF) is a core inflammatory factor in RA, which inhibits phosphatase and tensin homologue-induced kinase 1 (PINK1)-mediated mitophagy and elicits mitochondrial damage, which increases cytoplasmic mtDNA levels and activates cGAS-STING, boosting inflammation in RA (105) (Figure 2)

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These conditions also concern women who are not currently sexually active unless the treating physician considers that there are compelling reasons to indicate that there is no risk of pregnancy