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Medication injected directly from refrigerated storage might also intensify sensations by affecting local tissue response

doi: 10.1101/gad.283416.116 236 LiangXTangJLiangYJinRCaiX

Modifiable risk factors driving knee OA development include: Obesity it is estimated that every 5 kg (10 lb) of body weight increases knee OA risk by up to 35%

Bodies are naturally very efficient and need to be able to respond to any number of infections, so they dont want to waste resources maintaining the maximum level of defense forever against a pathogen they may or may not encounter