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Your body stays in that low sort of nutrient sensing state where autophagy can keep doing its thing

doi: 10.1111/j.1472-8206.1994.tb00832.x

Immune activation Your immune system ramps up inflammatory signaling to help clear debris (source)

EVs encapsulate cytoplasmic molecular cargo prior to release, including proteins, non-coding RNAs, and lipids, which are then distributed to nearby and distal cells

The mitochondria are central to energy production in all cells and are affected by iron overload, leading to mitochondrial oxidative stress and participation in ferroptosis ( Recent studies have highlighted the role of mitochondrial calcium uniporters (MCU) in mediating iron-induced mitochondrial dysfunction

Recent work has identified the endocannabinoid system (ECS) as a key mediator in lipotoxicity, with Cannabinoid receptor type 1 (CB1) activation promoting lipogenesis and inflammation (211)