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( B ) With the uptake of allergens or TLR (Toll-like receptor) ligands, DCs are progressively activated and undergo acute metabolic reprogramming, shifting from catabolism to anabolism

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This process may involve its metabolite sphingosine-1-phosphate (S1P), indicating that modulating the production of sphingolipid metabolites could be a viable approach for restoring the phagocytic function of AMs to treat COPD (113)

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It's also worth noting that vitamin C acts as an enzymatic cofactor in the hydroxylation of proline and lysine, a crucial step in collagen synthesis