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Cuproptosis: mechanisms and links with cancers [J]

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However, it was found that cisplatin-induced apoptosis is related to disbalance in the mGSH/GSSG ratio, decrease in NADPH(H + ) content, and oxidative damage of cardiolipin and aconitase, which disturbs the functioning of mitochondria and activates caspase-3 [78, 79]