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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

Zhang JZ, Ding Y, Xiang F, Yu SR, Zhang DZ, Guan MM, Kang XJ (2020) Effectiveness and safety of different doses of pioglitazone in psoriasis: a meta-analysis of randomized controlled trials

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Thats because excess body weight increases abdominal pressure, making it more likely for stomach acid to backflow