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Amedei A, Cappon A, Codolo G, Cabrelle A, Polenghi A, Benagiano M, Tasca E, Azzurri A, Delios MM, Del Prete G, De Bernard M (2006) The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses

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found that PF can reduce the release of pro-inflammatory cytokines by regulating TLR4/NF-B/NLRP3 signaling, thus reducing the damage of cytokines to neurons and reversing LPS-induced depression-like behavior in mice ( 6 IU/kg, as modeled by depression-inducing mice

Another study showed that PlMAPK1 plays a positive regulatory role in the plant response to heat stress (Qian et al., 2023)

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