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doi: 10.3389/fphar.2024.1508696 Received 10 October 2024 Accepted 23 December 2024 Published 15 January 2025 Volume 15 - 2024 Edited by Raul Chavez-Valdez, Johns Hopkins Medicine, United States Reviewed by Eric S

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pylori -infected participants with increased plasma ghrelin levels ( Plasma ghrelin levels increased with sham feeding in healthy controls and patients with idiopathic gastroparesis but not in patients with diabetic or postsurgical gastroparesis, indicative of a role for intact vagal signaling in the control of ghrelin release ( Subsequently, several ghrelin agonists have been studied, with a major focus on diabetic gastroparesis

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285 It can cross the blood-brain barrier, resulting in enhanced bioavailability, and research suggests it enhances GABA receptor activity in the brains hippocampus and exerts neuroprotective effects in the central nervous system