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According to what is stated above, Nrf2 inhibits ferroptosis through multiple pathways

Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation

Curcumin reverses resistance to gemcitabine through various mechanisms such as inhibiting drug efflux pumps, regulating signaling pathways (such as PI3K/AKT), and inducing specific modes of death (such as ferroptosis) (Namwa et al., 2025