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Long-term human safety and efficacy remain under investigation [4]

Similarly, a pilot study in 2015, a clinical trial (randomised) on 42 healthy human participants, receiving oral (tablet form) dosages of BPC 157 was carried out (Clinicaltrials.gov 2018): 0.25, 0.5, 1 and 2 g/kg

Shih, D

Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

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Molecular docking (MOE), alanine-substituted peptide library screening, and surface plasmon resonance (SPR) revealed that BPC157 binds FBXO22 through its proline residue at position 3 (P3)