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There is also evidence that FUS is involved in the cellular response to oxidative DNA damage, and it is well established that FUS has significant functions in DNA repair (Wang et al., 2013

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Mol Carcinog (2012) 51(3):23143

S4c) support the interpretation that differentiating cells undergo coordinated mitochondrial biogenesis, with both mitochondrial content and OXPHOS proteins increasing proportionally

Fumarate itself is a Michael acceptor, and the covalent attachment to protein cysteines corresponds to the post-translational modification known as succination [142] and fumarate has been recently demonstrated to yield a glutathione thioether in in vitro treated cells [142]

L., Tan, R