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The concomitant depletion of tryptophan and kynurenine may indicate impaired neuroprotective mechanisms or increased oxidative stress, aligning with the altered tryptophan metabolism observed with both NMR and UPLC/MS (Supplementary Figs

This interference can lead to altered mitochondrial morphology and function, which are the primary sources of ROS in cells (Zhou et al., 2020)

Nanotheranostics Development of theranostic platforms to investigate and modulate neuroinflammatory and neurodegenerative processes occurring during neurodegenerative disease progression, such as in AD, represents quite a novel and appealing strategy holding tremendous potential

It is water-soluble and should be stored refrigerated at 28 C

Many patients need both, in sequence or simultaneously

The treatment plates included NGM + 0.5 % (v/v) DMSO (vehicle control, Ctl), NGM + 250 M SIH, and NGM + 200 M Lip-1 (as described above)