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These models can be used not only to verify the pathogenicity of PD-related disease causative genes, but also to find appropriate interventions and therapeutic approaches

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Murine BMDCs were differentiated in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and/or Fms-related tyrosine kinase 3 ligand (FLT3L), alongside extracellular FA exposure during development and activation

Intravenous injection of urocortin 1 induces a CRF 2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats

In these cases, observational designs, such as prospective cohort studies that track naturally occurring risk factors over time, may provide stronger or more ethical evidence