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The facile trans-BBB migration of the engineered formulations through endocytosis, coupled with the inhibition of the P-gp efflux pump in the brain, was substantiated by the incorporation of Pluronic F-68 and/or polysorbate 80

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Furthermore, the complex and immunosuppressive tumor immune microenvironment also contributes to therapeutic resistance

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doi: 10.1007/s10067-017-3859-3 122 WjcikPGgotekAarkoviNSkrzydlewskaE

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