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An independent study showed that inhibition of enzymes involved in converting L-2-HG back to -KG also accounts for the resulting L-2-HG accumulation observed in acidic microenvironments 52

Conclusion High cocoa polyphenols rich chocolate 15 g three times daily improved fatigue and function in patients with chronic fatigue syndrome over a period of 8 weeks compared to simulated iso-calorific chocolate

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