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A real-world prospective cohort study including 2.2 million people demonstrated that the combination of SGLT-i and GLP-1 had better effects on all-cause mortality, MI and admission rate than SGLT-i or GLP-1 alone

These bioactive compounds play crucial roles in maintaining metabolic homeostasis, immune regulation, and endocrine function through multiple interconnected mechanisms ( At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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doi: 10.1016/j.drudis.2021.09.005 [DOI] [PubMed] [Google Scholar] 14.Kukut Hatipoglu M, Hickey AJ, Garcia-Contreras L