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There is increasing evidence that their role is limited in this population but may be beneficial for a small number of patients at a low dose in a managed setting [457]

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Because the number of trials within several strata was limited, these subgroup estimates and between-group comparisons should be interpreted cautiously

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doi: 10.1016/j.pep.2004.08.013 55 ViolanteSIJlstLte BrinkeHKosterJTavares de AlmeidaIWandersRJet al

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